Wilson Lim Selected Research

Mycetoma

6/2022	Eumycetoma causative agents are inhibited in vitro by luliconazole, lanoconazole and ravuconazole.
2/2022	Inhibiting DHN- and DOPA-melanin biosynthesis pathway increased the therapeutic value of itraconazole in Madurella mycetomatis infected Galleria mellonella.
1/2022	Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.
1/2022	Identifying novel drugs with new modes of action for neglected tropical fungal skin diseases (fungal skinNTDs) using an Open Source Drug discovery approach.
1/2021	The synthetic synergistic cinnamon oil CIN-102 is active against Madurella mycetomatis, the most common causative agent of mycetoma.
1/2021	Melanin production in coelomycetous agents of black grain eumycetoma.
1/2020	Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim.
1/2018	Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma.

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Wilson Lim Research Topics

Disease

8	Mycetoma 06/2022 - 01/2018
2	Neglected Diseases 01/2022 - 01/2018
1	Chromoblastomycosis (Chromomycosis) 01/2022
1	Dermatomycoses 01/2022
1	Malaria 01/2022
1	Sporotrichosis 01/2022
1	Invasive Fungal Infections 01/2020

Drug/Important Bio-Agent (IBA)

4	Pharmaceutical PreparationsIBA 06/2022 - 01/2018
3	Antifungal AgentsIBA 06/2022 - 01/2020
3	Itraconazole (Sporanox)FDA LinkGeneric 01/2022 - 01/2020
2	ER 30346 (ravuconazole)IBA 06/2022 - 01/2022
2	Melanins (Melanin)IBA 02/2022 - 01/2021
2	benzimidazoleIBA 01/2022 - 01/2022
2	olorofimIBA 01/2022 - 01/2020
2	CarbamatesIBA 01/2022 - 01/2022
1	luliconazoleIBA 06/2022
1	latoconazole (lanoconazole)IBA 06/2022
1	Terbinafine (Lamisil)FDA LinkGeneric 01/2022
1	FenbendazoleIBA 01/2022
1	CIN-102IBA 01/2021

Therapy/Procedure

1	Therapeutics 01/2020